I am seeing this problem, so far only on the ABV378E100 models in our district. Not happening on the 100 and ABV378 models with dark grey wide border. Windows 10×64 Version 20H2 OS build 19042.630
Opening sites in chrome browser causes the pen to stop being recognized. A reboot brings it back.
Teachers use dual monitors in extended mode, so do not want to go to HID mode from firmware update.